Association between metabolic deteriorations and prior gestational diabetes according to weight status. (29th November 2014)

• Record Type: Journal Article
• Authors: Vigneault, Jessica; Lemieux, Simone; Garneau, Véronique; Weisnagel, S. John; Tchernof, André; Robitaille, Julie
• Is Part Of: Obesity. Volume 23:Number 2(2015:Feb.)
• Page Start: 345
• Page End: 350
• Publication Date: 2014-11-29
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20940
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20940-sec-0001" sec-type="section"> <title>Objective</title> <p>The aim of the present study is to investigate the effect of prior gestational diabetes mellitus (GDM) on glucose and insulin homeostasis according to weight status.</p> </sec> <sec id="oby20940-sec-0002" sec-type="section"> <title>Methods</title> <p>The analysis included 299 women, 216 with [GDM(+)] and 83 without prior GDM [GDM(−)]. The mean time between pregnancy and testing was 3.9 years. Glucose values were obtained from a 2‐h 75 g oral glucose tolerance test (OGTT). Body composition was measured by dual‐energy X‐ray.</p> </sec> <sec id="oby20940-sec-0003" sec-type="section"> <title>Results</title> <p>In women with normal BMI, fasting glucose, 2‐h post‐OGTT glucose, and HbA<sub>1</sub> were higher for GDM(+) (<italic>P</italic> < 0.05). Normal‐weight women with GDM(+) presented lower HOMA‐IS, insulin secretion, and insulinogenic index (<italic>P</italic> < 0.05) compared to GDM(−). Body fat and android fat mass were higher, gynoid fat mass was similar, and lean body mass was decreased in GDM(+) vs. GDM(−) with normal weight (<italic>P</italic> < 0.05). A greater proportion of GDM(+) with overweight/obesity had prediabetes (72.1%) or type 2 diabetes (T2D) (21.7%) vs. GDM(−) and overweight/obesity (17.1 and 2.4%) or GDM(+) and normal weight (60.5 and 14.0%).</p> </sec> <sec id="oby20940-sec-0004" sec-type="section"> <title>Conclusions</title> <p>A combination of GDM and overweight/obesity is associated with T2D‐related metabolic deteriorations. Nevertheless, normal‐weight women with GDM(+) had increased android fat and greater metabolic complications, suggesting that women with prior GDM should benefit from lifestyle intervention, regardless of their weight status.</p> </sec> </abstract>