Correlation between mechanical stress by finite element analysis and 18F‐fluoride PET uptake in hip osteoarthritis patients. Issue 1 (23rd September 2014)

• Record Type: Journal Article
• Authors: Hirata, Yasuhide; Inaba, Yutaka; Kobayashi, Naomi; Ike, Hiroyuki; Yukizawa, Yohei; Fujimaki, Hiroshi; Tezuka, Taro; Tateishi, Ukihide; Inoue, Tomio; Saito, Tomoyuki
• Is Part Of: Journal of orthopaedic research. Volume 33:Issue 1(2015:Jan.)
• Page Start: 78
• Page End: 83
• Publication Date: 2014-09-23
• Subjects: Orthopedics -- Periodicals; Musculoskeletal system -- Periodicals; 616.7
• DOI: 10.1002/jor.22717
• Languages: English
• ISSNs: 0736-0266

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="jor22717-sec-0001" sec-type="section"> <p> <sup>18</sup>F‐fluoride positron emission tomography (<sup>18</sup>F‐fluoride PET) is a functional imaging modality used primarily to detect increased bone metabolism. Increased <sup>18</sup>F‐fluoride PET uptake suggests an association between increased bone metabolism and load stress at the subchondral level. This study therefore examined the relationship between equivalent stress distribution calculated by finite element analysis and <sup>18</sup>F‐fluoride PET uptake in patients with hip osteoarthritis. The study examined 34 hips of 17 patients who presented to our clinic with hip pain, and were diagnosed with osteoarthritis or pre‐osteoarthritis. The hips with trauma, infection, or bone metastasis of cancer were excluded. Three‐dimensional models of each hip were created from computed tomography data to calculate the maximum equivalent stress by finite element analysis, which was compared with the maximum standardized uptake value (SUV<sub>max</sub>) examined by <sup>18</sup>F‐fluoride PET. The SUV<sub>max</sub> and equivalent stress were correlated (Spearman's rank correlation coefficient ρ = 0.752), and higher equivalent stress values were noted in higher SUV<sub>max</sub> patients. The correlation between SUV<sub>max</sub> and maximum equivalent stress in osteoarthritic hips suggests the possibility that <sup>18</sup>F‐fluoride PET detect increased bone metabolism at sites of stress concentration. This study demonstrates the correlation between mechanical stress and bone remodeling acceleration in hip osteoarthritis. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:78–83, 2015.</p> </sec> </abstract>