Frontispiece: Lead Structures for New Antibacterials: Stereocontrolled Synthesis of a Bioactive Muraymycin Analogue. Issue 47 (17th November 2014)

• Record Type: Journal Article
• Authors: Spork, Anatol P.; Büschleb, Martin; Ries, Oliver; Wiegmann, Daniel; Boettcher, Stefan; Mihalyi, Agnes; Bugg, Timothy D. H.; Ducho, Christian
• Is Part Of: Chemistry. Volume 20:Issue 47(2014)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2014-11-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201484761
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Medicinal Chemistry</bold> Natural products and their analogues are particularly important for the development of novel antimicrobial agents. In their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 15292 ff., </ext-link> Ducho and co‐workers report on the efficient modular and stereocontrolled synthesis of a structurally simplified derivative of naturally occurring muraymycin nucleoside antibiotics. The obtained target compound showed promising biological properties and can, therefore, serve as a lead structure for future research on new antibacterials.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh3p8xw4vr" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>