Asymmetric Dual‐Reagent Catalysis: Mannich‐type Reactions Catalyzed by Ion Pair1. Issue 6 (16th December 2014)

• Record Type: Journal Article
• Authors: Wang, Hong‐Yu; Zhang, Kai; Zheng, Chang‐Wu; Chai, Zhuo; Cao, Dong‐Dong; Zhang, Jia‐Xing; Zhao, Gang
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 6(2015)
• Page Start: 1775
• Page End: 1779
• Publication Date: 2014-12-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201409342
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The combination of a new bifunctional phosphine and an acrylate generate a zwitterion in situ and it serves as an efficient catalyst for asymmetric reactions through a homogeneous ion‐pairing mode. This new catalytic system has been successfully applied to Mannich‐type reactions to give excellent results and it demonstrates a broad substrate scope. Such reactivity is not accessible with general organophosphine catalytic modes. Preliminary investigations into the mechanism are also presented.</p> </abstract>