A Drug–Perfluorocarbon Nanoemulsion with an Ultrathin Silica Coating for the Synergistic Effect of Chemotherapy and Ablation by High‐Intensity Focused Ultrasound. (16th September 2014)

• Record Type: Journal Article
• Authors: Ma, Ming; Xu, Huixiong; Chen, Hangrong; Jia, Xiaoqing; Zhang, Kun; Wang, Qi; Zheng, Shuguang; Wu, Rong; Yao, Minghua; Cai, Xiaojun; Li, Faqi; Shi, Jianlin
• Is Part Of: Advanced materials. Volume 26:Number 43(2014)
• Page Start: 7378
• Page End: 7385
• Publication Date: 2014-09-16
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201402969
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201402969-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The synergistic effect</bold> of chemotherapy and ablation using high‐intensity focused ultrasound (HIFU) is realized with a newly developed drug‐delivery system. The system comprises an ultrathin silica shell surrounding a poly(lactic‐co‐glycolic acid) nanoemulsion core containing the drug (CPT) and a perfluorocarbon (PFOB). This nanosystem presents many advantages in drug delivery, such as excellent structural stability, high drug‐loading capacity, and rapid HIFU‐mediated drug release. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh3m33ttt0" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>