Testis sparing surgery in the treatment of bilateral testicular germ cell tumors and solitary testicle tumors: A single institution experience. Issue 2 (5th September 2014)

• Record Type: Journal Article
• Authors: Bojanic, Nebojsa; Bumbasirevic, Uros; Vukovic, Ivan; Bojanic, Gordana; Milojevic, Bogomir; Nale, Djordje; Durutovic, Otas; Djordjevic, Dejan; Nikic, Predrag; Vuksanovic, Aleksandar; Tulic, Cane; Micic, Sava
• Is Part Of: Journal of surgical oncology. Volume 111:Issue 2(2015:Feb. 01)
• Page Start: 226
• Page End: 230
• Publication Date: 2014-09-05
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23777
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jso23777-sec-0001" sec-type="section"> <title>Background and Objective</title> <p>To assess the oncologic and functional outcomes of testicular sparing surgery (TSS) based on a single institution experience.</p> </sec> <sec id="jso23777-sec-0002" sec-type="section"> <title>Methods</title> <p>Forty‐one patients with bilateral and 3 patients with solitary testicle tumors were referred to our institution. The inclusion criteria for TSS were normal serum testosterone levels, and tumor size (<2 cm). Sperm analysis and hormone status evaluation were performed preoperatively and postoperatively. None of the patients underwent local radiation therapy following TSS for reasons of fertility preservation.</p> </sec> <sec id="jso23777-sec-0003" sec-type="section"> <title>Results</title> <p>A total of 26 TSS were performed in 24 patients. The median follow‐up period was 51.0 months. Seven patients developed local recurrence, of which 5 had TIN and were subjected to radical orchiectomy, whereas re‐do TSS was done in remaining 2 patients. The overall survival of the study group was 100%, and the presence of testicular intraepithelial neoplasia (TIN) was associated with worse recurrence‐free survival (<italic>P</italic> = 0.031, log‐rank). Testosterone values were normal in all of the patients, while 4 patients achieved conception.</p> </sec> <sec id="jso23777-sec-0004" sec-type="section"> <title>Conclusions</title> <p>TSS is acceptable from an oncological point of view, and it enables continuation of a patient's life without lifelong hormonal substitution. Additionally, local irradiation therapy could be delayed in patients with TIN who wish to father children, but with high local recurrence rate. <italic>J. Surg. Oncol. 2015 111:226–230</italic>. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>