Site‐ and Regioselectivity of the Reaction of Hydrazonoyl Chlorides with Perimidine Ketene Aminal. Antimicrobial Evaluation of the Products. (5th May 2014)

• Record Type: Journal Article
• Authors: Farghaly, Thoraya A.; Mahmoud, Huda K.
• Is Part Of: Journal of heterocyclic chemistry. Volume 52:Number 1(2015:Jan.)
• Page Start: 86
• Page End: 91
• Publication Date: 2014-05-05
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.1985
• Languages: English
• ISSNs: 0022-152X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Reaction of hydrazonoyl chlorides with perimidine ketene aminal derivative in dioxane in the presence of triethylamine afforded either pyrrolo[1, 2‐<italic>a</italic>]perimidines or pyrazolyl perimidines depending on the type of hydrazonoyl chloride used. The reaction was found to be site‐ and <named-content content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">regioselective</named-content> according to the suggested mechanism. The structure of the newly synthesized compounds was established on the basis of spectral data and elemental analyses. In addition, the <named-content content-type="chemicalTechnology" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">antimicrobial activity</named-content> of the newly synthesized compounds was evaluated, and the results showed moderate activity of all compounds against the bacterial species.</p> </abstract>