Obstructive Sleep Apnea and Metabolic Bone Disease: Insights Into the Relationship Between Bone and Sleep. (February 2015)

• Record Type: Journal Article
• Authors: Swanson, Christine M; Shea, Steven A; Stone, Katie L; Cauley, Jane A; Rosen, Clifford J; Redline, Susan; Karsenty, Gerard; Orwoll, Eric S
• Is Part Of: Journal of bone and mineral research. Volume 30:Number 2(2015:Feb.)
• Page Start: 199
• Page End: 211
• Publication Date: 2015-02
• Subjects: Bones -- Metabolism -- Periodicals; Mineral metabolism -- Periodicals; 612.392
• DOI: 10.1002/jbmr.2446
• Languages: English
• ISSNs: 0884-0431

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>ABSTRACT</title> <sec id="jbmr2446-sec-0001" sec-type="section"> <p>Obstructive sleep apnea (OSA) and low bone mass are two prevalent conditions, particularly among older adults—a section of the U.S. population that is expected to grow dramatically over the coming years. OSA, the most common form of sleep‐disordered breathing, has been linked to multiple cardiovascular, metabolic, hormonal, and inflammatory derangements and may have adverse effects on bone. However, little is known about how OSA (including the associated hypoxia and sleep loss) affects bone metabolism. In order to gain insight into the relationship between sleep and bone, we review the growing information on OSA and metabolic bone disease and discuss the pathophysiological mechanisms by which OSA may affect bone metabolism/architecture. © 2015 American Society for Bone and Mineral Research</p> </sec> </abstract>