Thyroid autoimmunity and risk of malignancy in thyroid nodules submitted to fine‐needle aspiration cytology. Issue 2 (3rd April 2014)

• Record Type: Journal Article
• Authors: Grani, Giorgio; Calvanese, Anna; Carbotta, Giovanni; D'Alessandri, Mimma; Nesca, Angela; Bianchini, Marta; Del Sordo, Marianna; Vitale, Martina; Fumarola, Angela
• Is Part Of: Head & neck. Volume 37:Issue 2(2015:Feb.)
• Page Start: 260
• Page End: 264
• Publication Date: 2014-04-03
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23587
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="hed23587-sec-0001" sec-type="section"> <title>Background</title> <p>Whether the risk of cancer is increased in patients with chronic autoimmune thyroiditis is a controversial issue.</p> </sec> <sec id="hed23587-sec-0002" sec-type="section"> <title>Methods</title> <p>Between May 2005 and October 2012, 3777 fine‐needle aspiration cytologies (FNACs) were performed on 2562 patients. Serum FT4, thyroid‐stimulating hormone (TSH), anti‐thyroglobulin antibody (TgAb), and anti‐thyroperoxidase antibody (TPOAb) were determined.</p> </sec> <sec id="hed23587-sec-0003" sec-type="section"> <title>Results</title> <p>Patients with suspicious cytology were younger and presented smaller maximum lesion diameter. In patients with TgAb positivity, suspicious cytology was detected more frequently (9.4%) than patients without TgAb (5.7%; <italic>p</italic> = .04). No significant difference was recorded between benign and suspicious cytology in the positive TPOAb rate. Risk factors for suspicious cytology were younger age (odds ratio [OR], 0.94), smaller maximum diameter (0.95), single lesion (1.85), microcalcifications (3.45), and TgAb (1.74). Mixed solid/fluid content resulted as being a protective factor (0.34). According to multivariate logistic regression analysis, age, mixed content, and microcalcification confirmed significance.</p> </sec> <sec id="hed23587-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Thyroid nodule malignancy in patients with Hashimoto thyroiditis is not more frequent than in patients without thyroiditis. © 2014 Wiley Periodicals, Inc. <italic>Head Neck</italic><bold>37</bold>: 260‐264, 2015</p> </sec> </abstract>