The relationship between exposure to air pollution and sperm disomy. (3rd July 2014)

• Record Type: Journal Article
• Authors: Jurewicz, Joanna; Radwan, Michał; Sobala, Wojciech; Polańska, Kinga; Radwan, Paweł; Jakubowski, Lucjusz; Ulańska, Anna; Hanke, Wojciech
• Is Part Of: Environmental and molecular mutagenesis. Volume 56:Number 1(2015:Jan.)
• Page Start: 50
• Page End: 59
• Publication Date: 2014-07-03
• Subjects: Mutagenesis -- Periodicals; Molecular genetics -- Periodicals; Mutagenèse -- Périodiques; Mutagenèse chimique -- Périodiques; Mutation -- Périodiques; Maladies de l'environnement -- Périodiques; Génétique moléculaire -- Périodiques; 576.542
• DOI: 10.1002/em.21883
• Languages: English
• ISSNs: 0893-6692

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The causes of the chromosome abnormalities have been studied for decades. It has been suggested that exposure to various environmental agents can induce chromosomal abnormalities in germ cells. This study was designed to address the hypothesis that exposure to specific air pollutants increases sperm disomy. The study population consisted of 212 men who were attending an infertility clinic for diagnostic purposes. They represented a subset of men in a multicenter parent study conducted in Poland to evaluate environmental factors and male fertility. Sperm aneuploidy for chromosomes 13, 18, 21, X, and Y was assessed using multicolor fluorescence in situ hybridization. Air quality data were obtained from the AirBase database. After adjusting for age, smoking, alcohol consumption, temperature (90 days), season, past diseases, abstinence interval, distance from the monitoring station, concentration, motility and morphology, positive associations were observed between exposure to PM<sub>2.5</sub> and disomy Y (<italic>P</italic> = 0.001), sex chromosome disomy (<italic>P</italic> = 0.05) and disomy 21 (<italic>P</italic> = 0.03). Exposure to PM<sub>10</sub> was associated with disomy 21 (<italic>P</italic> = 0.02). Conversely, exposure to ozone, CO, SO<sub>2</sub>, and NOx did not affect sperm aneuploidy. A separate analysis conducted among men who were nonsmokers (<italic>n</italic> = 117) showed that the relationship between PM<sub>2.5</sub> and disomy Y and disomy 21 remained significant (<italic>P</italic> = 0.01, <italic>P</italic> = 0.05, respectively). The present findings indicate that exposure to air pollution induces sperm aneuploidy. Environ. Mol. Mutagen. 56:50–59, 2015. © 2014 Wiley Periodicals, Inc.</p> </abstract>