Cardiac CT and echocardiographic evaluation of peri‐device flow after percutaneous left atrial appendage closure using the AMPLATZER cardiac plug device. Issue 2 (4th October 2014)

• Record Type: Journal Article
• Authors: Jaguszewski, Milosz; Manes, Costantina; Puippe, Gilbert; Salzberg, Sacha; Müller, Maja; Falk, Volkmar; Lüscher, Thomas; Luft, Andreas; Alkadhi, Hatem; Landmesser, Ulf
• Is Part Of: Catheterization and cardiovascular interventions. Volume 85:Issue 2(2015:Feb. 01)
• Page Start: 306
• Page End: 312
• Publication Date: 2014-10-04
• Subjects: Heart -- Diseases -- Diagnosis -- Periodicals; Cardiac catheterization -- Periodicals; 616.1207572
• DOI: 10.1002/ccd.25667
• Languages: English
• ISSNs: 1522-1946

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ccd25667-sec-0001" sec-type="section"> <title>Objectives</title> <p>The aim of the study was to examine frequency, size, and localization of peri‐device leaks after percutaneous left atrial appendage (LAA)‐closure with the AMPLATZER‐Cardiac‐Plug (ACP) by using a multimodal imaging approach, i.e. combined cardiac‐CT and TEE follow‐up.</p> </sec> <sec id="ccd25667-sec-0002" sec-type="section"> <title>Background</title> <p>Catheter‐based LAA‐occlusion using ACP aims to reduce the risk of stroke in patients with atrial fibrillation. Detection of peri‐device leaks after ACP implantation by TEE is challenging, the few available data are inconsistent and the frequency of LAA leaks after ACP implantation remains therefore unclear.</p> </sec> <sec id="ccd25667-sec-0003" sec-type="section"> <title>Methods</title> <p>Cardiac‐CT using a multi‐phase protocol and a second‐generation dual‐source‐CT‐system was performed in 24 patients with non‐valvular atrial fibrillation starting 3 months after LAA‐closure by ACP. Color Doppler multiplane TEE was used to evaluate peri‐device flow.</p> </sec> <sec id="ccd25667-sec-0004" sec-type="section"> <title>Results</title> <p>Cardiac‐CT follow‐up detected any persistent LAA contrast filling in 62% of patients (<italic>n</italic> = 15), but leak‐sizes were small (1.5 ± 1.4 mm). Peri‐device leaks were almost exclusively localized at the posterior portion of the LAA‐orifice (>90%). TEE follow‐up revealed peri‐device flow in 36% of patients (jet‐sizes: ≤ 4 mm). ACP‐lobe compression (>10%) and perpendicular ACP‐lobe orientation to the LAA‐neck axis, that was also dependent on LAA anatomy, were substantially more frequent in patients with complete LAA closure.</p> </sec> <sec id="ccd25667-sec-0005" sec-type="section"> <title>Conclusion</title> <p>The present study evaluates for the first time peri‐device flow after LAA closure by ACP using a combined cardiac‐CT and TEE follow‐up. Persistent LAA‐perfusion was frequently detected, leak‐sizes were small and were less frequent when lobe compression was >10% and lobe orientation was perpendicular to the LAA‐neck axis, that was also related to the LAA anatomy. The clinical significance of these small leaks after LAA‐closure using ACP needs to be further evaluated in future studies. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>