Polymorphism of SLC25A32, the folate transporter gene, is associated with plasma folate levels and bone fractures in Japanese postmenopausal women. Issue 4 (5th December 2013)

• Record Type: Journal Article
• Authors: Urano, Tomohiko; Shiraki, Masataka; Saito, Mitsuru; Sasaki, Noriko; Ouchi, Yasuyoshi; Inoue, Satoshi
• Is Part Of: Geriatrics and gerontology international. Volume 14:Issue 4(2014)
• Page Start: 942
• Page End: 946
• Publication Date: 2013-12-05
• Subjects: Geriatrics -- Periodicals; Gerontology -- Periodicals; Geriatrics -- Japan -- Periodicals; Gerontology -- Japan -- Periodicals; 618.97
• DOI: 10.1111/ggi.12201
• Languages: English
• ISSNs: 1444-1586

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ggi12201-sec-0001" sec-type="section"> <title>Aim</title> <p>Elevation of homocysteine is associated with an increased risk for bone fractures. We previously reported that the methylenetetrahydrofolate reductase (<italic>MTHFR</italic>) gene polymorphism is associated with homocysteine levels and fracture. The association between the fracture and folate levels or their related gene polymorphisms is not completely clear. We speculated that the <italic>SLC25A32</italic> gene, the mitochondrial inner membrane folate transporter, also could be implicated in the regulation of folate metabolism and fracture.</p> </sec> <sec id="ggi12201-sec-0002" sec-type="section"> <title>Methods</title> <p>A total of 851 Japanese postmenopausal women participated in the association study between the single nucleotide polymorphism genotype and plasma homocysteine or folate. We also tested the association between the candidate single nucleotide polymorphism and 663 postmenopausal women.</p> </sec> <sec id="ggi12201-sec-0003" sec-type="section"> <title>Results</title> <p>The AA genotype of rs2241777 single nucleotide polymorphism at the 3′UTR region in the <italic>SLC25A32</italic> gene was associated with lower plasma folate concentration compared with the other genotypes in 851 postmenopausal women. A total of 674 postmenopausal ambulatory Japanese women were followed up for 5.5 ± 0.1 years (mean ± SE). The AA genotype groups also showed an apparently higher rate and earlier onset of incident fractures than the other genotypes. A total of 407 participants had >70% young‐adult mean bone mineral density at the start of the observation.</p> </sec> <sec id="ggi12201-sec-0004" sec-type="section"> <title>Conclusions</title> <p>These results show that the <italic>SLC25A32</italic> gene polymorphism could be a risk factor for lower folate concentration and future fracture. <bold>Geriatr Gerontol Int 2014; 14: 942–946.</bold></p> </sec> </abstract>