In Vitro Assays of Mitochondrial Function/Dysfunction. Issue 6 (10th September 2014)

• Record Type: Journal Article
• Authors: Than, T A; Win, S; Kaplowitz, N
• Is Part Of: Clinical pharmacology & therapeutics. Volume 96:Issue 6(2014)
• Page Start: 665
• Page End: 668
• Publication Date: 2014-09-10
• Subjects: Pharmacology -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1038/clpt.2014.178
• Languages: English
• ISSNs: 0009-9236

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>In drug‐induced hepatotoxicity, type 2 diabetes, and alcoholic and nonalcoholic fatty liver diseases, liver mitochondria have been recognized to be dysfunctional. Mitochondrial function can be assessed in isolated mitochondria and in intact cells by using O₂‐dependent quenching of porphyrin‐based phosphors or by using amperometric O₂ sensors to measure O₂ consumption.</p> <p> <italic>Clinical Pharmacology &amp; Therapeutics</italic> (2014); <bold>96</bold> 6, 665–668. doi:<ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">10.1038/clpt.2014.178</ext-link></p> </abstract>