TRIM family proteins: emerging class of RING E3 ligases as regulator of NF‐κB pathway. (14th November 2014)

• Record Type: Journal Article
• Authors: Tomar, Dhanendra; Singh, Rajesh
• Is Part Of: Biology of the cell. Volume 107:Number 1(2015:Jan.)
• Page Start: 22
• Page End: 40
• Publication Date: 2014-11-14
• Subjects: Cytology -- Periodicals; Electron microscopy -- Periodicals; 571.6
• DOI: 10.1111/boc.201400046
• Languages: English
• ISSNs: 0248-4900

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="boc201400046-abs-0001"> <title>Review</title> <p>TRIMs modulate NF‐κB signalling in response to numerous extracellular or intracellular stimuli. TRIM proteins acts at various steps of NF‐κB signalling cascade starting from receptor stimulation, assembly of cytoplasmic IKK signalosomes, regulating degradation of IκBα and translocation of NF‐κB to the nucleus. TRIMs also regulate the degradation of inhibitors of NF‐κB, binding and transcription in the nucleus. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh30vfr6gz" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>