Inflammatory biomarker pentraxin 3 (PTX3) in relation to obesity, body fat depots and weight loss. (25th January 2014)

• Record Type: Journal Article
• Authors: Witasp, Anna; Carrero, Juan Jesús; Michaëlsson, Karl; Ahlström, Håkan; Kullberg, Joel; Adamsson, Viola; Risérus, Ulf; Larsson, Anders; Helmersson‐Karlqvist, Johanna; Lind, Lars; Stenvinkel, Peter; Ärnlöv, Johan
• Is Part Of: Obesity. Volume 22:Number 5(2014:May)
• Page Start: 1373
• Page End: 1379
• Publication Date: 2014-01-25
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20695
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20695-sec-0001" sec-type="section"> <title>Objective</title> <p>The relation between inflammatory markers, adiposity and disease is under extensive study. Here we tested the hypothesis that the immunomodulatory protein pentraxin 3 (PTX3) is associated with adiposity in the general population.</p> </sec> <sec id="oby20695-sec-0002" sec-type="section"> <title>Methods</title> <p>Serum PTX3 concentrations, body mass index (BMI), waist circumference (WC) and fat depots, as quantified by dual‐energy X‐ray absorptiometry and magnetic resonance imaging, were assessed in three community‐based cohorts: ULSAM, <italic>n</italic> = 790, mean age 78 years; PIVUS, <italic>n</italic> = 1003, mean age 70 years, women 50%; and the NORDIET‐trial, <italic>n</italic> = 86, mean age 53 years, women 63%. Participants were re‐examined after 5 years (PIVUS, <italic>n</italic> = 804) or following a 6‐week randomized controlled dietary intervention (NORDIET).</p> </sec> <sec id="oby20695-sec-0003" sec-type="section"> <title>Results</title> <p>PTX3 levels were inversely associated with BMI and WC as well as with total and visceral fat (<italic>P</italic> < 0.05 for all; adjusted for age, inflammatory biomarkers and cardiovascular risk factors). The association between PTX3 and BMI appeared even stronger in nonobese individuals. A decrease in BMI over 5 years as well as weight loss following the NORDIET intervention were associated with increased serum PTX3 concentrations (<italic>P</italic> < 0.001).</p> </sec> <sec id="oby20695-sec-0004" sec-type="section"> <title>Conclusions</title> <p>These consistent data support an inverse association between circulating PTX3 and anthropometrical measures, calling for further mechanistic studies of the link between PTX3 and fat.</p> </sec> </abstract>