Directed CH Alkenylation of Quinoline N‐Oxides at the C‐8 Position Using a Cationic Rhodium(I) Catalyst. Issue 7 (30th April 2014)

• Record Type: Journal Article
• Authors: Shibata, Takanori; Matsuo, Yusuke
• Is Part Of: Advanced synthesis & catalysis. Volume 356:Issue 7(2014)
• Page Start: 1516
• Page End: 1520
• Publication Date: 2014-04-30
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201400223
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The cationic rhodium‐catalyzed alkenylation proceeds at the C‐8 position of quinoline <italic>N</italic>‐oxides. Regioselective CH bond activation was achieved by the directing effect of the anionic oxygen of an <italic>N</italic>‐oxide moiety, which can be readily removed by reductive treatment. A variety of 8‐alkenylated quinoline <italic>N</italic>‐oxides was obtained in moderate to high yields.</p> <p> <boxed-text content-type="graphic" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh5bvtpk" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> </abstract>