Palladium‐Catalyzed Direct Alkynylation of N‐Vinylacetamides. Issue 7 (30th April 2014)

• Record Type: Journal Article
• Authors: Xu, Yun‐He; Zhang, Qiu‐Chi; He, Tao; Meng, Fei‐Fan; Loh, Teck‐Peng
• Is Part Of: Advanced synthesis & catalysis. Volume 356:Issue 7(2014)
• Page Start: 1539
• Page End: 1543
• Publication Date: 2014-04-30
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201400171
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A direct ethynylation reaction between <italic>N</italic>‐vinylacetamides and (bromoethynyl)triisopropylsilane catalyzed by palladium is reported. A broad scope of cyclic <italic>N</italic>‐vinylacetamide derivatives was tolerated and the corresponding products could be obtained in acceptable yields. This work provides a general tool for the synthesis of conjugated enyne products using palladium(II) acetate as catalyst. The mild reaction conditions and reasonable results should make this method a useful synthetic protocol. Unfortunately, other bromo‐substituted alkynes are found to be unreactive and could not afford the desired products under the current reaction conditions.</p> <p> <boxed-text content-type="graphic" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh5bwcct" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> </abstract>