Rectal cancer: Dynamic contrast‐enhanced MRI correlates with lymph node status and epidermal growth factor receptor expression. Issue 6 (11th October 2013)

• Record Type: Journal Article
• Authors: Lollert, André; Junginger, Theodor; Schimanski, Carl Christoph; Biesterfeld, Stefan; Gockel, Ines; Düber, Christoph; Oberholzer, Katja
• Is Part Of: Journal of magnetic resonance imaging. Volume 39:Issue 6(2014)
• Page Start: 1436
• Page End: 1442
• Publication Date: 2013-10-11
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24301
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24301-sec-0001" sec-type="section"> <title>Purpose</title> <p>To evaluate correlations between dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) and clinicopathologic data as well as immunostaining of the markers of angiogenesis epidermal growth factor receptor (EGFR) and CXC‐motif chemokine receptor 4 (CXCR4) in patients with rectal cancer.</p> </sec> <sec id="jmri24301-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Presurgical DCE‐MRI was performed in 41 patients according to a standardized protocol. Two quantitative parameters (k<sub>21</sub>, A) were derived from a pharmacokinetic two‐compartment model, and one semiquantitative parameter (TTP) was assessed. Standardized surgery and histopathologic examinations were performed in all patients. Immunostaining for EGFR and CXCR4 was performed and evaluated with a standardized scoring system.</p> </sec> <sec id="jmri24301-sec-0003" sec-type="section"> <title>Results</title> <p>DCE‐MRI parameter A correlated significantly with the N category (<italic>P</italic> = 0.048) and k<sub>21</sub> with the occurrence of synchronous and metachronous distant metastases (<italic>P</italic> = 0.029). A trend was shown toward a correlation between k<sub>21</sub> and EGFR expression (<italic>P</italic> = 0.107). A significant correlation was found between DCE‐MRI parameter TTP and the expression of EGFR (<italic>P</italic> = 0.044). DCE‐MRI data did not correlate with CXCR4 expression.</p> </sec> <sec id="jmri24301-sec-0004" sec-type="section"> <title>Conclusion</title> <p>DCE‐MRI is a noninvasive method which can characterize microcirculation in rectal cancer and correlates with EGFR expression. Given the relationship between the dynamic parameters and the clinicopathologic data, DCE‐MRI data may constitute a prognostic indicator for lymph node and distant metastases in patients with rectal cancer. <bold>J. Magn. Reson. Imaging 2014;39:1436–1442</bold>. © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>