Elucidating Common Structural Features of Human Pathogenic Variations Using Large‐Scale Atomic‐Resolution Protein Networks. Issue 5 (7th April 2014)
- Record Type:
- Journal Article
- Title:
- Elucidating Common Structural Features of Human Pathogenic Variations Using Large‐Scale Atomic‐Resolution Protein Networks. Issue 5 (7th April 2014)
- Main Title:
- Elucidating Common Structural Features of Human Pathogenic Variations Using Large‐Scale Atomic‐Resolution Protein Networks
- Authors:
- Das, Jishnu
Lee, Hao Ran
Sagar, Adithya
Fragoza, Robert
Liang, Jin
Wei, Xiaomu
Wang, Xiujuan
Mort, Matthew
Stenson, Peter D.
Cooper, David N.
Yu, Haiyuan - Abstract:
- <abstract abstract-type="graphical" xml:lang="en" id="humu22534-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We combine the scale of network systems biology with the resolution of traditional structural biology to generate a large‐scale atomic‐resolution interactome‐network comprising 3, 398 interactions between 2, 890 proteins with a well‐defined interaction interface and interface residues for each interaction. Using this atomic‐resolution network, we elucidate key structural principles underlying variations causing human inherited disease. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg5ndpg862" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>
- Is Part Of:
- Human mutation. Volume 35:Issue 5(2014:May)
- Journal:
- Human mutation
- Issue:
- Volume 35:Issue 5(2014:May)
- Issue Display:
- Volume 35, Issue 5 (2014)
- Year:
- 2014
- Volume:
- 35
- Issue:
- 5
- Issue Sort Value:
- 2014-0035-0005-0000
- Page Start:
- 585
- Page End:
- 593
- Publication Date:
- 2014-04-07
- Subjects:
- Human chromosome abnormalities -- Periodicals
Mutation (Biology) -- Periodicals
616.04205 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-1004 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/humu.22534 ↗
- Languages:
- English
- ISSNs:
- 1059-7794
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4336.217000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 3305.xml