Monocyte‐derived dendritic cells identified as booster of T follicular helper cell differentiation. Issue 5 (May 2014)

• Record Type: Journal Article
• Authors: Fillatreau, Simon
• Is Part Of: EMBO molecular medicine. Volume 6:Issue 5(2014:May)
• Page Start: 574
• Page End: 576
• Publication Date: 2014-05
• Subjects: Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.1002/emmm.201404015
• Languages: English
• ISSNs: 1757-4676

Abstract

<abstract abstract-type="main" id="emmm201404015-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p content-type="executiveSummary">Adjuvants play an essential role in the induction of acquired immunity upon vaccination with protein antigen. In this issue of <italic>EMBO Molecular Medicine</italic>, a classical type of adjuvant made of DNA oligonucleotide containing CpG motifs, which has already been used in humans, is shown to boost humoral immunity primarily by acting on monocyte‐derived dendritic cells. This study provides novel insight on the mode of action of adjuvant targeting Toll‐like receptors.</p> </abstract>