Gene Delivery: Nonendocytic Delivery of Lipoplex Nanoparticles into Living Cells Using Nanochannel Electroporation (Adv. Healthcare Mater. 5/2014). Issue 5 (May 2014)

• Record Type: Journal Article
• Authors: Boukany, Pouyan E.; Wu, Yun; Zhao, Xi; Kwak, Kwang J.; Glazer, Piotr J.; Leong, Kam; Lee, L. James
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 5(2014:May)
• Page Start: 622
• Page End: 622
• Publication Date: 2014-05
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201470023
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adhm201470023-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Pouyan E. Boukany, L. James Lee, and colleagues have now found a safe, and efficient way to deliver nanoparticles containing a wide range of therapeutic agents into living cells without going through the endocytosis route, by applying electrical pulses through a nanochannel. The nanofluidic device introduced on page 682 represents a novel platform for in vitro nucleic acid delivery in regulating gene expression and holds great potential in advancing fundamental biological science and modifying cells for biomedical applications. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg5nnd655d" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>