Nucleic Acid Based Logical Systems. Issue 20 (1st April 2014)

• Record Type: Journal Article
• Authors: Han, Da; Kang, Huaizhi; Zhang, Tao; Wu, Cuichen; Zhou, Cuisong; You, Mingxu; Chen, Zhuo; Zhang, Xiaobing; Tan, Weihong
• Is Part Of: Chemistry. Volume 20:Issue 20(2014)
• Page Start: 5866
• Page End: 5873
• Publication Date: 2014-04-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201304891
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Researchers increasingly visualize a significant role for artificial biochemical logical systems in biological engineering, much like digital logic circuits in electrical engineering. Those logical systems could be utilized as a type of servomechanism to control nanodevices in vitro, monitor chemical reactions in situ, or regulate gene expression in vivo. Nucleic acids (NA), as carriers of genetic information with well‐regulated and predictable structures, are promising materials for the design and engineering of biochemical circuits. A number of logical devices based on nucleic acids (NA) have been designed to handle various processes for technological or biotechnological purposes. This article focuses on the most recent and important developments in NA‐based logical devices and their evolution from in vitro, through cellular, even towards in vivo biological applications.</p> </abstract>