Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. (March 2014)

• Record Type: Journal Article
• Authors: Yu, C.-W.; Wei, C.-C.; Liao, V. H.-C.
• Is Part Of: Free radical research. Volume 48:Number 3(2014:Mar.)
• Page Start: 371
• Page End: 379
• Publication Date: 2014-03
• Subjects: Free radicals (Chemistry) -- Periodicals; Antioxidants -- Periodicals; Vitamin C -- Periodicals; Vitamin E -- Periodicals; 541.224
• DOI: 10.3109/10715762.2013.872779
• Languages: English
• ISSNs: 1071-5762

Abstract

<abstract> <title>Abstract</title> <p>Curcumin (diferuloylmethane), a pharmacologically active substance derived from turmeric, exhibits anti-inflammatory, anticarcinogenic, and antioxidant properties. We examined the modulation of oxidative-stress resistance and associated regulatory mechanisms by curcumin in a <italic>Caenorhabditis elegans</italic> model. Our results showed that curcumin-treated wild-type <italic>C. elegans</italic> exhibited increased survival during juglone-induced oxidative stress compared with the control treatment. In addition, curcumin reduced the levels of intracellular reactive oxygen species in <italic>C. elegans</italic>. Moreover, curcumin induced the expression of the <italic>gst-4</italic> and <italic>hsp-16.2</italic> stress response genes. Lastly, our findings from the mechanistic study in this investigation suggest that the antioxidative effect of curcumin is mediated via regulation of <italic>age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1</italic>, and <italic>mev-1</italic>. Our study elucidates the diverse modes of action and signaling pathways that underlie the antioxidant activity exhibited by curcumin in vivo.</p> </abstract>