Cyclosporin A therapy on idiopathic thrombotic thrombocytopenic purpura in the relapse setting: two case reports and a review of the literature. Issue 7 (1st November 2012)

• Record Type: Journal Article
• Authors: Yilmaz, Murvet; Eskazan, Ahmet Emre; Unsal, Abdulkadir; Taninmis, Hakan; Kara, Ekrem; Cetiner, Mustafa; Ferhanoglu, Burhan
• Is Part Of: Transfusion. Volume 53:Issue 7(2013)
• Page Start: 1586
• Page End: 1593
• Publication Date: 2012-11-01
• Subjects: Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; Blood Group Antigens -- Periodicals; Blood Preservation -- Periodicals; Blood Transfusion -- Periodicals; 615
• DOI: 10.1111/j.1537-2995.2012.03944.x
• Languages: English
• ISSNs: 0041-1132

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="trf3944-sec-0001" sec-type="section"> <title>Background</title> <p>Thrombotic thrombocytopenic purpura (TTP) is a life‐threatening disease, characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, neurologic disturbances, and renal failure. Plasma therapy has dramatically improved prognosis of TTP, whereas recurrent acute episodes still occur in approximately 40% of patients. Moreover, patients with acquired ADAMTS13 deficiency, which is a significant factor for relapse, may require additional immunosuppressive treatment to get a durable remission.</p> </sec> <sec id="trf3944-sec-0002" sec-type="section"> <title>Study Design and Methods</title> <p>We hereby report two patients with a history of relapsed idiopathic TTP, who both received cyclosporin A (CSA) as a prophylactic manner after the remission was achieved. We also discuss the efficacy of CSA in patients with relapsed idiopathic TTP with a review of the published literature.</p> </sec> <sec id="trf3944-sec-0003" sec-type="section"> <title>Results</title> <p>Under CSA therapy, both patients maintained their clinical remission state, and the ADAMTS13 levels were normalized.</p> </sec> <sec id="trf3944-sec-0004" sec-type="section"> <title>Conclusion</title> <p>To conclude, CSA therapy may be useful for the prevention of relapsed idiopathic TTP in patients with a history of frequent relapses.</p> </sec> </abstract>