Pregnancy following ovarian induction in a patient with premature ovarian failure and undetectable serum anti‐Müllerian hormone. Issue 5 (4th February 2013)

• Record Type: Journal Article
• Authors: Tsuji, Isao; Ami, Kazumi; Fujinami, Nahoko
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 39:Issue 5(2013:May)
• Page Start: 1070
• Page End: 1072
• Publication Date: 2013-02-04
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/j.1447-0756.2012.02068.x
• Languages: English
• ISSNs: 1341-8076

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>We report the first case, to the best of our knowledge, of successful conception following ovarian induction in a patient with premature ovarian failure and undetectable serum anti‐Müllerian hormone. A 34‐year‐old woman was referred because of ovarian amenorrhea. After endogenous gonadotrophins were normalized by hormone‐replacement therapy and gonadotrophin‐releasing hormone agonist, ovarian induction was performed using exogenous gonadotrophins. On ovarian induction day 8, one follicle had reached a mean diameter of 19.6 mm, the serum estradiol level had increased to 516 pg/mL, and human chorionic gonadotrophin (HCG) was injected. On HCG injection day 7, ultrasonography was unable to detect the follicle, and serum progesterone levels had increased to 6.1 ng/mL. One month after HCG injection, ultrasonography detected an intrauterine fetus with beating heart. Even with serum anti‐Müllerian hormone levels below the threshold of detection, there is a chance for patients with premature ovarian failure.</p> </abstract>