Oxytocin versus sustained‐release dinoprostone vaginal pessary for labor induction of unfavorable cervix with Bishop score ≥4 and ≤6: A randomized controlled trial. Issue 4 (20th November 2012)

• Record Type: Journal Article
• Authors: Koc, Onder; Duran, Bülent; Ozdemirci, Safak; Albayrak, Mustafa; Koc, Ummugulsum
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 39:Issue 4(2013:Apr.)
• Page Start: 790
• Page End: 798
• Publication Date: 2012-11-20
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/j.1447-0756.2012.02045.x
• Languages: English
• ISSNs: 1341-8076

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jog2045-sec-0001" sec-type="section"> <title>Aim</title> <p>To compare the efficacy and safety of high‐dose intravenous oxytocin and sustained‐release dinoprostone vaginal pessaries for cervical ripening and labor induction in pregnant patients at term with poor Bishop scores.</p> </sec> <sec id="jog2045-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>Women at term with a Bishop score ≥4 and ≤6 were randomized into two groups to undergo induction of labor with either high‐dose oxytocin administered intravenously (<italic>n</italic> = 90) or dinoprostone‐only vaginal pessary without oxytocin augmentation (<italic>n</italic> = 90). The main outcome measures were rate of cesarean delivery, induction to delivery interval, number of deliveries achieved within 4, 8, 12, and 16 h of labor induction, maternal complications during induction, fetal outcome, and total hospital stay. In this study, per‐protocol analysis was performed.</p> </sec> <sec id="jog2045-sec-0003" sec-type="section"> <title>Results</title> <p>There were fewer cesarean deliveries with oxytocin compared to dinoprostone‐only groups (7/79 vs 14/89); however, the difference was not statistically significant. The induction–delivery intervals (7.9 h vs 12.0 h, <italic>P</italic> < 0.001; and 5.7 vs 10.4 h, <italic>P</italic> < 0.001; oxytocin vs dinoprostone‐only for primiparous and multiparous patients, respectively) were significantly shorter in oxytocin‐induced patients compared to dinoprostone‐only. A significantly higher percentage of patients delivered in the oxytocin group compared to the dinoprostone‐only group in 4, 8, 12, 16, and 20 h.</p> </sec> <sec id="jog2045-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Intravenous oxytocin is effective to stimulate labor at term for patients with Bishop scores ≥4 and ≤6, with a shorter time interval from induction to vaginal delivery.</p> </sec> </abstract>