Diastolic Abnormalities in Normal Phenotype Hypertrophic Cardiomyopathy Gene Carriers: A Study Using Speckle Tracking Echocardiography. Issue 5 (10th December 2012)

• Record Type: Journal Article
• Authors: Kauer, Floris; van Dalen, Bas M.; Michels, Michelle; Soliman, Osama I. I.; Vletter, Wim B.; van Slegtenhorst, Marjon; ten Cate, Folkert J.; Geleijnse, Marcel L.
• Is Part Of: Echocardiography. Volume 30:Issue 5(2013)
• Page Start: 558
• Page End: 563
• Publication Date: 2012-12-10
• Subjects: Echocardiography -- Periodicals; Echocardiography -- Periodicals; 616.1207543
• DOI: 10.1111/echo.12076
• Languages: English
• ISSNs: 0742-2822

Abstract

<abstract abstract-type="main" id="echo12076-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="echo12076-sec-0001" sec-type="section"> <title>Background</title> <p>Tissue Doppler imaging (TDI) of the mitral annulus has been proposed as an alternative for the identification of hypertrophic cardiomyopathy (HCM) genetically affected subjects without left ventricular hypertrophy (G+/LVH−). Unfortunately, conflicting results have been described in the literature, potentially caused by the angle‐dependency of TDI. This study sought to assess abnormalities in mitral annular velocities in G+/LVH− subjects as detected by speckle tracking echocardiography (STE).</p> </sec> <sec id="echo12076-sec-0002" sec-type="section"> <title>Methods</title> <p>The study population consisted of 23 consecutive genotyped family members without major or minor criteria for the diagnosis of HCM (mean age 37 ± 13 years, 9 men) and 23 healthy volunteers (age 38 ± 12 years, 12 men) who prospectively underwent STE.</p> </sec> <sec id="echo12076-sec-0003" sec-type="section"> <title>Results</title> <p>There were no significant differences in global peak systolic annular velocity (7.4 ± 1.2 vs. 7.1 ± 1.0 cm/sec) and early diastolic annular velocity (10.2 ± 2.5 vs. 11.3 ± 2.2 cm/sec) between G+/LVH− and control subjects. Global peak late diastolic annular velocity was higher in G+/LVH− subjects (8.1 ± 1.7 vs. 5.7 ± 1.1 cm/sec, P < 0.001). Regionally, this difference was seen in all 6 studied LV walls.</p> </sec> <sec id="echo12076-sec-0004" sec-type="section"> <title>Conclusions</title> <p>This STE study confirms our previous TDI observations on increased peak late diastolic annular velocities in G+/LVH− subjects. Because of the complete overlap in early diastolic annular velocities this parameter cannot be used in the genotypes we studied to differentiate genotype (+) from genotype (−) individuals.</p> </sec> </abstract>