Impaired Coronary Microvascular Function and Its Association with Disease Duration and Inflammation in Patients with Psoriasis. Issue 8 (12th March 2013)

• Record Type: Journal Article
• Authors: Gullu, Hakan; Caliskan, Mustafa; Dursun, Recep; Ciftci, Ozgur; Guven, Aytekin; Muderrisoglu, Haldun
• Is Part Of: Echocardiography. Volume 30:Issue 8(2013)
• Page Start: 912
• Page End: 918
• Publication Date: 2013-03-12
• Subjects: Echocardiography -- Periodicals; Echocardiography -- Periodicals; 616.1207543
• DOI: 10.1111/echo.12156
• Languages: English
• ISSNs: 0742-2822

Abstract

<abstract abstract-type="main" xml:lang="en" id="echo12156-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="echo12156-sec-0001" sec-type="section"> <title>Subjects</title> <p>Thirty‐six patients with psoriasis and 56 healthy volunteers were included in this study.</p> </sec> <sec id="echo12156-sec-0002" sec-type="section"> <title>Methods</title> <p>Echocardiographic examination included transmitral peak flow velocities of the early phase (E) and late phase (A) of the mitral inflow, left ventricular myocardial velocity measurements, and coronary flow reserve (CFR) measurement.</p> </sec> <sec id="echo12156-sec-0003" sec-type="section"> <title>Results</title> <p>Baseline coronary diastolic peak flow velocity (DPFV) of left anterior descending artery (LAD) was significantly higher in the psoriasis group. However, hyperemic DPFV was slightly lower and CFR (2.19 ± 0.39 vs. 2.60 ± 0.31, P<italic> </italic>&lt;<italic> </italic>0.0001) was significantly lower in the psoriasis group than in the control group. CFR was significantly and inversely correlated with disease duration, Psoriasis Area and Severity Index (PASI) score, and hsCRP.</p> </sec> <sec id="echo12156-sec-0004" sec-type="section"> <title>Conclusion</title> <p>CFR is decreased in patients with psoriasis, and it correlates to disease duration, PASI score, and inflammation.</p> </sec> </abstract>