Independent Role of Left Ventricular Global Longitudinal Strain in Predicting Prognosis of Chronic Heart Failure Patients. Issue 7 (14th March 2013)

• Record Type: Journal Article
• Authors: Iacoviello, Massimo; Puzzovivo, Agata; Guida, Pietro; Forleo, Cinzia; Monitillo, Francesco; Catanzaro, Raffaella; Lattarulo, Maria Silvia; Antoncecchi, Valeria; Favale, Stefano
• Is Part Of: Echocardiography. Volume 30:Issue 7(2013)
• Page Start: 803
• Page End: 811
• Publication Date: 2013-03-14
• Subjects: Echocardiography -- Periodicals; Echocardiography -- Periodicals; 616.1207543
• DOI: 10.1111/echo.12142
• Languages: English
• ISSNs: 0742-2822

Abstract

<abstract abstract-type="main" xml:lang="en" id="echo12142-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="echo12142-sec-0001" sec-type="section"> <title>Aims</title> <p>To evaluate the independent prognostic role of two‐dimensional (2D) strain measures reflecting global longitudinal left ventricular (LV) systolic function in outpatients affected by chronic heart failure (CHF).</p> </sec> <sec id="echo12142-sec-0002" sec-type="section"> <title>Methods and results</title> <p>Global longitudinal LV systolic strain (GLS) was assessed in 308 outpatients affected by CHF, by analyzing standard views with 2D speckle tracking technique. During a mean follow‐up of 26 ± 13 months 37 patients died (29 due to cardiovascular causes), 10 patients underwent heart transplantation, and 75 patients experienced at least 1 episode of hospitalization due to acute decompensated heart failure (ADHF). Thirty‐one patients without a history of major ventricular arrhythmic events experienced the occurrence of ventricular fibrillation and/or tachycardia or sudden death was observed. Multivariate Cox regression analysis showed that GLS was significantly associated with all‐cause mortality (HR: 1.15; 95%CI: 1.02–1.30; P: 0.026), cardiovascular death (HR: 1.20; 95%CI: 1.04–1.39; P: 0.011), cardiovascular death or heart transplantation (HR: 1.24; 95%CI: 1.09–1.41; P: 0.001), ADHF‐related hospitalizations (HR: 1.15; 95%CI: 1.05–1.25; P: 0.003), and arrhythmic events (HR: 1.17; 95%CI: 1.03–1.33; P: 0.018).</p> </sec> <sec id="echo12142-sec-0003" sec-type="section"> <title>Conclusions</title> <p>Quantifying LV longitudinal systolic function in CHF outpatients on the basis of 2D speckle tracking analysis provides a new parameter that independently predicts patient outcome, thus, strengthening its possible role in current clinical practice.</p> </sec> </abstract>