A Family of Hydrazone‐Based Nucleosides for Use in Metal‐Mediated Base Pairs1. Issue 8 (19th March 2013)

• Record Type: Journal Article
• Authors: Radunsky, Christian; Megger, Dominik A.; Hepp, Alexander; Kösters, Jutta; Freisinger, Eva; Müller, Jens
• Is Part Of: Zeitschrift für anorganische und allgemeine Chemie. Volume 639:Issue 8/9(2013)
• Page Start: 1621
• Page End: 1627
• Publication Date: 2013-03-19
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1002/zaac.201300061
• Languages: English
• ISSNs: 0044-2313

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A new family of hydrazone‐based nucleosides for use in metal‐mediated base pairs was devised. The artificial nucleobases are derivatives of the papy ligand (papy = pyridinecarboxaldehyde‐2′‐pyridylhydrazone). By replacing the pendant pyridine moiety in papy by furan and thiophene, respectively, tridentate nucleosides with N, N, N‐, N, N, O‐ and N, N, S‐donor sites were obtained. As only a few transition metal complexes with pendant furan ligands have been reported, a model nucleobase for the N, N, O‐donor nucleoside was synthesized. The molecular structures of its Cu²⁺, Ni²⁺, and Co²⁺ complexes are reported. In all complexes, only weak <italic>M</italic>–O(furan) bonding is observed. The Co²⁺ complex displays a pentagonal bipyramidal coordination arrangement. In general, the structures of the metal complexes suggest that the respective nucleosides can be applied in metal‐mediated base pairs.</p> </abstract>