High‐Purity Prostate Circulating Tumor Cell Isolation by a Polymer Nanofiber‐Embedded Microchip for Whole Exome Sequencing. (26th March 2013)

• Record Type: Journal Article
• Authors: Zhao, Libo; Lu, Yi‐Tsung; Li, Fuqiang; Wu, Kui; Hou, Shuang; Yu, Juehua; Shen, Qinglin; Wu, Dongxia; Song, Min; OuYang, Wei‐Han; Luo, Zheng; Lee, Tom; Fang, Xiaohong; Shao, Chen; Xu, Xun; Garcia, Mitch A.; Chung, Leland W. K.; Rettig, Matthew; Tseng, Hsian‐Rong; Posadas, Edwin M.
• Is Part Of: Advanced materials. Volume 25:Number 21(2013)
• Page Start: 2897
• Page End: 2902
• Publication Date: 2013-03-26
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201205237
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Handpick single cancer cells:</bold> A modified NanoVelcro Chip is coupled with ArcturusXT laser capture microdissection (LCM) technology to enable the detection and isolation of single circulating tumor cells (CTCs) from patients with prostate cancer (PC). This new approach paves the way for conducting next‐generation sequencing (NGS) on single CTCs. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg21ffnrk6" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>