Ultrathin PEGylated W18O49 Nanowires as a New 980 nm‐Laser‐Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo1. (21st February 2013)

• Record Type: Journal Article
• Authors: Chen, Zhigang; Wang, Qian; Wang, Huanli; Zhang, Lisha; Song, Guosheng; Song, Linlin; Hu, Junqing; Wang, Hongzhi; Liu, Jianshe; Zhu, Meifang; Zhao, Dongyuan
• Is Part Of: Advanced materials. Volume 25:Number 14(2013)
• Page Start: 2095
• Page End: 2100
• Publication Date: 2013-02-21
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201204616
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A new photothermal coupling agent for photothermal ablation (PTA) therapy</bold> of tumors is developed based on ultrathin PEGylated W₁₈O₄₉ nanowires. After being injected with the nanowire solution, the in vivo tumors exhibit a rapid temperature rise to 50.0 ± 0.5 °C upon irradiation with NIR laser light at a safe, low intensity (0.72 W cm⁻²) for 2 min (left‐hand mouse in the figure), ), resulting in the efficient PTA of cancer cells in vivo in 10 min. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1x46nsr4" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>