Silica‐Based Branched Hollow Microfibers as a Biomimetic Extracellular Matrix for Promoting Tumor Cell Growth In Vitro and In Vivo. (1st March 2013)

• Record Type: Journal Article
• Authors: Qiu, Penghe; Qu, Xuewei; Brackett, Daniel J.; Lerner, Megan R.; Li, Dong; Mao, Chuanbin
• Is Part Of: Advanced materials. Volume 25:Number 17(2013)
• Page Start: 2492
• Page End: 2496
• Publication Date: 2013-03-01
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201204472
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A novel scaffold composed of loosely branched hollow silica microfibers</bold> that has been proven to be highly biocompatible is proposed for the 3D culture of cancer cells. The MCF‐7 cancer cells can grow and proliferate freely inside the scaffold in the form of multicellular spheroids. MCF‐7 cancer cells cultured on the current 3D silica scaffold retained significantly more oncological characters than those cultured on the conventional 2D substrate and can serve as in vitro tumor model for studying cancer treatment. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1zskf278" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>