Highly Discriminating Photorelease of Anticancer Drugs Based on Hypoxia Activatable Phototrigger Conjugated Chitosan Nanoparticles. (7th February 2013)

• Record Type: Journal Article
• Authors: Lin, Qiuning; Bao, Chunyan; Yang, Yunlong; Liang, Qiannan; Zhang, Dasheng; Cheng, Shuiyu; Zhu, Linyong
• Is Part Of: Advanced materials. Volume 25:Number 14(2013)
• Page Start: 1981
• Page End: 1986
• Publication Date: 2013-02-07
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201204455
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>An ultimately selective photorelease system of chitosan‐nanoparticles</bold> is constructed. Only under unique aspects of tumor‐hypoxia physiological conditions, the preliminary locked phototrigger is unlocked by biological reduction to enable the release of the caged drug either by visible light or two‐photon near‐IR (NIR) excitation. This approach provides a highly discriminating photorelease of anticancer drug to hypoxic tumor cells, but not to healthy normal cells. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1x46ntv9" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>