Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles. Issue 34 (9th July 2013)

• Record Type: Journal Article
• Authors: Mas, Núria; Galiana, Irene; Mondragón, Laura; Aznar, Elena; Climent, Estela; Cabedo, Nuria; Sancenón, Félix; Murguía, José Ramón; Martínez‐Máñez, Ramón; Marcos, María D.; Amorós, Pedro
• Is Part Of: Chemistry. Volume 19:Issue 34(2013)
• Page Start: 11167
• Page End: 11171
• Publication Date: 2013-07-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201302170
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Bug busters</bold>: A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with ε‐poly‐<sc>L</sc>‐lysine (ε‐PL) was prepared and its interaction with different Gram‐negative bacteria studied (see figure). A remarkable improvement in the efficacy of the antimicrobial drug ε‐PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36r49mt3" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>