Total Synthesis and Structural Revision of Laurefurenynes A and B. Issue 38 (19th August 2013) - Holmes, Michael T.
Abstract Structural reassignment: A total synthesis of the proposed structure of (−)‐laurefurenyne A has been accomplished that relies on organocatalytic aldehyde α‐chlorination and a flexible chlorohydrin‐based strategy for stereocontrolled access to the bis‐tetrahydrofuran core of the natural product. Analysis of incongruities between the 1H NMR spectra of synthetic and natural material led to a configurational reassignment for the natural product, which was also confirmed by total synthesis.