Rh‐Catalyzed Direct Enantioselective Alkynylation of α‐Ketiminoesters. Issue 26 (13th May 2013)

• Record Type: Journal Article
• Authors: Morisaki, Kazuhiro; Sawa, Masanao; Nomaguchi, Jun‐ya; Morimoto, Hiroyuki; Takeuchi, Yosuke; Mashima, Kazushi; Ohshima, Takashi
• Is Part Of: Chemistry. Volume 19:Issue 26(2013)
• Page Start: 8417
• Page End: 8420
• Publication Date: 2013-05-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201301237
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A green way to amino acids</bold>: α‐Tetrasubstituted α‐amino acid derivatives are formed in high yield and enantioselectivity by using a Rh‐catalyzed enantioselective alkynylation of α‐ketiminoesters. This reaction, which involves a proton transfer and can be conducted at room temperature, has high substrate scope (see scheme; Cbz=benzyloxycarbonyl, Fmoc=9‐fluorenylmethyloxycarbonyl).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg2245t28c" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>