Development of a Metal‐Ion‐Mediated Base Pair for Electron Transfer in DNA. Issue 37 (26th July 2013)

• Record Type: Journal Article
• Authors: Ehrenschwender, Thomas; Schmucker, Wolfgang; Wellner, Christian; Augenstein, Timo; Carl, Patrick; Harmer, Jeffrey; Breher, Frank; Wagenknecht, Hans‐Achim
• Is Part Of: Chemistry. Volume 19:Issue 37(2013)
• Page Start: 12547
• Page End: 12552
• Publication Date: 2013-07-26
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201300593
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A new C‐nucleoside structurally based on the hydroxyquinoline ligand was synthesized that is able to form stable pairs in DNA in both the absence and the presence of metal ions. The interactions between the metal centers in adjacent Cu^II‐mediated base pairs in DNA were probed by electron paramagnetic resonance (EPR) spectroscopy. The metal–metal distance falls into the range of previously reported values. Fluorescence studies with a donor–DNA–acceptor system indicate that photoinduced charge‐transfer processes across these metal‐ion‐mediated base pairs in DNA occur more efficiently than over natural base pairs.</p> </abstract>