Catalytic Asymmetric Construction of Quaternary α‐Amino Acid Containing Pyrrolidines through 1, 3‐Dipolar Cycloaddition of Azomethine Ylides to α‐Aminoacrylates. Issue 21 (28th March 2013)

• Record Type: Journal Article
• Authors: Wang, Zheng; Luo, Shuai; Zhang, Shoude; Yang, Wu‐Lin; Liu, Yang‐Zi; Li, Honglin; Luo, Xiaoyan; Deng, Wei‐Ping
• Is Part Of: Chemistry. Volume 19:Issue 21(2013)
• Page Start: 6739
• Page End: 6745
• Publication Date: 2013-03-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201300204
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The first catalytic enantioselective 1, 3‐dipolar cycloaddition of azomethine ylides to α‐aminoacrylate catalyzed by a AgOAc/ferrocenyl oxazolinylphosphine (FOXAP) system was developed, which exhibits excellent <italic>exo‐</italic> and enantioselectivity (92–99 % <italic>ee</italic>). This process provides efficient access to useful 4‐aminopyrrolidine‐2, 4‐dicarboxylic acid (APDC)‐like compounds containing a unique quaternary α‐amino acid unit.</p> </abstract>