Synthesis of Fluorine‐Containing Multisubstituted Phenanthridines by Rhodium‐Catalyzed Alkyne [2+2+2] Cycloaddition and Tandem sp2 CH Difluoromethylenation. Issue 25 (24th April 2013)

• Record Type: Journal Article
• Authors: Li, Yajun; Zhu, Jiangtao; Zhang, Lisi; Wu, Yongming; Gong, Yuefa
• Is Part Of: Chemistry. Volume 19:Issue 25(2013)
• Page Start: 8294
• Page End: 8299
• Publication Date: 2013-04-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201300288
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A highly efficient method for the synthesis of fluorine‐containing multisubstituted phenanthridines through Rh‐catalyzed alkyne [2+2+2] cycloaddition reactions has been developed. This method exhibits excellent functional‐group compatibility. When a bromodifluoromethyl group, rather than a trifluoromethyl group, was employed in the cycloaddition reaction, more‐complicated polycyclic compounds were obtained through tandem Rh‐catalyzed cycloaddition/CH difluoromethylenation. This route provides convenient access to fluorine‐containing polycyclic compounds.</p> </abstract>