Cyclic isoDGR Peptidomimetics as Low‐Nanomolar αvβ3 Integrin Ligands. Issue 11 (19th February 2013)

• Record Type: Journal Article
• Authors: Mingozzi, Michele; Dal Corso, Alberto; Marchini, Mattia; Guzzetti, Ileana; Civera, Monica; Piarulli, Umberto; Arosio, Daniela; Belvisi, Laura; Potenza, Donatella; Pignataro, Luca; Gennari, Cesare
• Is Part Of: Chemistry. Volume 19:Issue 11(2013)
• Page Start: 3563
• Page End: 3567
• Publication Date: 2013-02-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201204639
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A perfect fit</bold>: Shown here is the docking best pose of a low‐nanomolar α_vβ₃ integrin ligand <italic>cyclo</italic>[DKP‐<italic>iso</italic>DGR] (atom color tube representation; see figure) into the receptor binding pocket, overlaid on the bound conformation of Cilengitide (green tube representation). The extended <italic>iso</italic>DGR conformation permits all the important interactions with the extracellular domain of the α_vβ₃ integrin. The metal ion in the MIDAS region is represented by a magenta sphere.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1tsnwnf1" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>