Cooperative Iron–Brønsted Acid Catalysis: Enantioselective Hydrogenation of Quinoxalines and 2 H‐1, 4‐Benzoxazines. Issue 16 (5th March 2013)

• Record Type: Journal Article
• Authors: Fleischer, Steffen; Zhou, Shaolin; Werkmeister, Svenja; Junge, Kathrin; Beller, Matthias
• Is Part Of: Chemistry. Volume 19:Issue 16(2013)
• Page Start: 4997
• Page End: 5003
• Publication Date: 2013-03-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201204236
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Come together!</bold> A selective Fe‐catalysed enantioselective reduction of quinoxalines and benzoxazines with hydrogen is demonstrated. Key to success is the combination of a chiral Brønsted acid and a well‐defined non‐chiral Fe hydrogenation catalyst. This methodology constitutes an attractive and environmentally favourable alternative to well‐established asymmetric hydrogenations by using precious‐metal‐based catalysts.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1x529jsv" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>