Catalytic Enantioselective Decarboxylative Cyanoalkylation of Imines by Using Palladium Pincer Complexes with C2‐Symmetric Chiral Bis(imidazoline)s. Issue 13 (27th February 2013)

• Record Type: Journal Article
• Authors: Hyodo, Kengo; Kondo, Masaru; Funahashi, Yasuhiro; Nakamura, Shuichi
• Is Part Of: Chemistry. Volume 19:Issue 13(2013)
• Page Start: 4128
• Page End: 4134
• Publication Date: 2013-02-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201203782
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Manifold products</bold>: The enantioselective decarboxylative Mannich‐type reaction of cyanoacetic acid with <italic>N</italic>‐ (2‐pyridinesulfonyl)imines catalyzed by chiral 1, 3‐bis(imidazolin‐2‐yl)benzene (Phebim)–Pd^II complexes afforded products with good enantioselectivity (see scheme). The reaction was applied to a wide range of imines with good yield and enantioselectivity. The obtained products can be converted into various compounds without the loss of enantiopurity.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v8cpv0n" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>