Serum vitamin D levels are inversely related with non‐alcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women. (February 2015)

• Record Type: Journal Article
• Authors: Lu, Zhigang; Pan, Xiaoping; Hu, Yaqin; Hao, Yaping; Luo, Yuqi; Hu, Xiang; Ma, Xiaojing; Bao, Yuqian; Jia, Weiping
• Is Part Of: Clinical and experimental pharmacology and physiology. Volume 42:Number 2(2015:Feb.)
• Page Start: 139
• Page End: 145
• Publication Date: 2015-02
• Subjects: Clinical pharmacology -- Periodicals; Pharmacology, Experimental -- Periodicals; Physiology, Experimental -- Periodicals; Physiology, Pathological -- Periodicals; 615.1
• DOI: 10.1111/1440-1681.12334
• Languages: English
• ISSNs: 0305-1870

Abstract

<abstract abstract-type="main" id="cep12334-abs-0001"> <title>Summary</title> <p>The aim of the present study was to investigate the association between serum vitamin D levels and both visceral adipose and with non‐alcoholic fatty liver disease (NAFLD) in Chinese postmenopausal women. Four hundred and fifty‐one postmenopausal women between 45 and 74 years of age (mean (± SD) age 57.3 ± 4.6 years) were enrolled in the study. All subjects participated in the Shanghai Obesity Study between June and August 2011 and underwent abdominal magnetic resonance imaging and an abdominal ultrasonography. Patients with a visceral fat area (VFA) ≥ 80 cm<sup>2</sup> were classified as abdominally obese. Serum 25‐hydroxyvitamin D<sub>3</sub> (25(OH)D<sub>3</sub>) levels were measured with an electrochemiluminescence immunoassay. The prevalence of NAFLD in the study population was 34.8% (<italic>n</italic> = 157). Women with abdominal obesity had significantly lower serum 25(OH)D<sub>3</sub> levels than those without abdominal obesity (median (interquartile range) 11.23 (8.64–14.12) <italic>vs</italic> 12.56 (9.41–15.98) ng/mL, respectively; <italic>P</italic> < 0.01). Regardless of abdominal obesity status, serum 25(OH)D<sub>3</sub> levels in patients with NAFLD were lower than those without non‐NAFLD (11.14 (8.63–13.81) <italic>vs</italic> 12.92 (9.48–16.37) ng/mL (<italic>P</italic> < 0.05) for those without abdominal obesity; 10.86 (8.61–13.56) <italic>vs</italic> 11.55 (8.82–16.38) ng/mL (<italic>P</italic> < 0.05) for those with abdominal obesity). Partial correlation analyses demonstrated a negative correlation between serum 25(OH)D<sub>3</sub> levels and VFA (<italic>P </italic>< 0.05). Logistic regression analysis revealed that high serum 25(OH)D<sub>3</sub> levels were a protective factor against NAFLD after adjusting for risk factors such as VFA. In conclusion, independent of visceral obesity, vitamin D is inversely correlated with NAFLD in Chinese postmenopausal women.</p> </abstract>