Cytological characteristics of papillary thyroid carcinoma on LBC specimens, compared with conventional specimens. Issue 2 (28th June 2014)

• Record Type: Journal Article
• Authors: Suzuki, Ayana; Hirokawa, Mitsuyoshi; Higuchi, Miyoko; Yamao, Naoki; Kuma, Seiji; Nakamura, Hirotoshi; Amino, Nobuyuki; Miyauchi, Akira
• Is Part Of: Diagnostic cytopathology. Volume 43:Issue 2(2015:Feb.)
• Page Start: 108
• Page End: 113
• Publication Date: 2014-06-28
• Subjects: Cytodiagnosis -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Periodicals; 616.07582
• DOI: 10.1002/dc.23191
• Languages: English
• ISSNs: 8755-1039

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="dc23191-sec-0101" sec-type="section"> <title>Background</title> <p>The cytological findings in conventional specimens (C‐S) and liquid‐based cytology specimens (LBC‐S) are not quite same. The aim of this article is to clarify the cytological findings of papillary thyroid carcinoma (PTC) characteristic of LBC‐S.</p> </sec> <sec id="dc23191-sec-0102" sec-type="section"> <title>Methods</title> <p>Out of 5, 971 cases diagnosed in a single institution from March to September in 2012, 161 PTC cases with both C‐S and LBC‐S were reviewed. Additionally, we compared the findings with those in LBC‐S of 55 adenomatous or hyperplastic nodule (AN) and 21 follicular neoplasm (FN) cases.</p> </sec> <sec id="dc23191-sec-0103" sec-type="section"> <title>Results</title> <p>Compared to C‐S, the incidences of trabecular and hobnail patterns, collagenous stroma, naked capillaries, intercellular spaces, convoluted nuclei, eosinophilic nucleoli, and perinucleolar halo were increased. Pale nuclei were observed in only one of 161 PTC cases. Specificity of convoluted nuclei and perinucleolar halo were 97.4% and 96.1%, respectively.</p> </sec> <sec id="dc23191-sec-0104" sec-type="section"> <title>Conclusion</title> <p>Convoluted nuclei and perinucleolar halo might become a new indicator of PTC in LBC‐S. Contrarily, we should be aware that pale nuclei are rarely observed in LBC‐S. Diagn. Cytopathol. 2015;43:108–113. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>