Facile preparation of boronic acid‐functionalized magnetic nanoparticles with a high capacity and their use in the enrichment of cis‐diol‐containing compounds from plasma. (25th July 2014)
- Record Type:
- Journal Article
- Title:
- Facile preparation of boronic acid‐functionalized magnetic nanoparticles with a high capacity and their use in the enrichment of cis‐diol‐containing compounds from plasma. (25th July 2014)
- Main Title:
- Facile preparation of boronic acid‐functionalized magnetic nanoparticles with a high capacity and their use in the enrichment of cis‐diol‐containing compounds from plasma
- Authors:
- Du, Jin
He, Maofang
Wang, Xiaomeng
Fan, Hua
Wei, Yinmao - Abstract:
- <abstract abstract-type="main"> <title>Abstract</title> <p>The use of bronate affinity adsorbents is a new separation method that appeared recently with great potential for specific extraction of <italic>cis</italic>‐diol‐containing compounds. In this work, a new strategy for the facile construction of boronic acid‐functionalized Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles (Fe<sub>3</sub>O<sub>4</sub>@FPBA MNPs) with a high capacity was described. The extraction capacity of the Fe<sub>3</sub>O<sub>4</sub>@FPBA MNPs was determined to be 66.0 ± 2.7 µmol/g for catechol and 80.6 ± 2.0 µmol/g for dopamine, being higher than that for the reported methods. The Fe<sub>3</sub>O<sub>4</sub>@FPBA MNPs were used to extract four <italic>cis</italic>‐diol drugs: caffeic acid isopropyl ester, caffic acid bornyl ester, isopropyl 3‐(3, 4‐dihydroxyphenyl)‐2‐hydroxypropanoate and 3‐(3, 4‐dihydroxyphenyl)‐2‐hydroxylpropionic acid – from the spiked rabbit plasma, and the recoveries of four drugs were between 87.29 and104.37% with relative standard deviations ranging from 1.34 to 8.81%. Under the most favorable conditions, the solid‐phase extraction combined with HPLC‐UV for the analysis of four drugs in plasma could eliminate interferences from endogenous components of the biological fluids and exhibited sufficient precision and accuracy. These results showed that the prepared Fe<sub>3</sub>O<sub>4</sub>@FPBA MNPs were qualified for efficiently enriching and determining the trace<abstract abstract-type="main"> <title>Abstract</title> <p>The use of bronate affinity adsorbents is a new separation method that appeared recently with great potential for specific extraction of <italic>cis</italic>‐diol‐containing compounds. In this work, a new strategy for the facile construction of boronic acid‐functionalized Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles (Fe<sub>3</sub>O<sub>4</sub>@FPBA MNPs) with a high capacity was described. The extraction capacity of the Fe<sub>3</sub>O<sub>4</sub>@FPBA MNPs was determined to be 66.0 ± 2.7 µmol/g for catechol and 80.6 ± 2.0 µmol/g for dopamine, being higher than that for the reported methods. The Fe<sub>3</sub>O<sub>4</sub>@FPBA MNPs were used to extract four <italic>cis</italic>‐diol drugs: caffeic acid isopropyl ester, caffic acid bornyl ester, isopropyl 3‐(3, 4‐dihydroxyphenyl)‐2‐hydroxypropanoate and 3‐(3, 4‐dihydroxyphenyl)‐2‐hydroxylpropionic acid – from the spiked rabbit plasma, and the recoveries of four drugs were between 87.29 and104.37% with relative standard deviations ranging from 1.34 to 8.81%. Under the most favorable conditions, the solid‐phase extraction combined with HPLC‐UV for the analysis of four drugs in plasma could eliminate interferences from endogenous components of the biological fluids and exhibited sufficient precision and accuracy. These results showed that the prepared Fe<sub>3</sub>O<sub>4</sub>@FPBA MNPs were qualified for efficiently enriching and determining the trace <italic>cis</italic>‐diol substances from biological samples. Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract> … (more)
- Is Part Of:
- Biomedical chromatography. Volume 29:Number 2(2015:Feb.)
- Journal:
- Biomedical chromatography
- Issue:
- Volume 29:Number 2(2015:Feb.)
- Issue Display:
- Volume 29, Issue 2 (2015)
- Year:
- 2015
- Volume:
- 29
- Issue:
- 2
- Issue Sort Value:
- 2015-0029-0002-0000
- Page Start:
- 312
- Page End:
- 320
- Publication Date:
- 2014-07-25
- Subjects:
- Chromatographic analysis -- Periodicals
Biology -- Periodicals
Medicine -- Periodicals
Biology -- Periodicals
Chromatography -- methods -- Periodicals
Medicine -- Periodicals
543.089 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/bmc.3277 ↗
- Languages:
- English
- ISSNs:
- 0269-3879
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 2087.758000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 3707.xml