Early second trimester retinol‐binding protein‐4 values in cases with or without gestational diabetes mellitus risk factors: A cross‐sectional study. Issue 1 (17th September 2014)

• Record Type: Journal Article
• Authors: Yarci Gursoy, Asli; Aynaoglu, Gulsah; Caglar, Gamze Sinem; Soylemez, Feride
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 41:Issue 1(2015:Jan.)
• Page Start: 55
• Page End: 61
• Publication Date: 2014-09-17
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.12499
• Languages: English
• ISSNs: 1341-8076

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jog12499-sec-0001" sec-type="section"> <title>Aim</title> <p>Retinol‐binding protein‐4 (RBP‐4) has been correlated with different degrees of insulin resistance including gestational diabetes mellitus (GDM). Presence of risk factors for GDM is an indication for early screening. We studied RBP‐4 values in the early second trimester of pregnancy in pregnant subjects with or without GDM risk factors and compared the results by routine GDM screening methodology.</p> </sec> <sec id="jog12499-sec-0002" sec-type="section"> <title>Methods</title> <p>Seventy‐nine patients with at least one GDM risk factor and 46 patients without any GDM risk factors were enrolled in the cross‐sectional study as risk and control groups, respectively. In the early second trimester, RBP‐4 values were measured, in addition to fasting plasma glucose and 50‐g glucose challenge test in all subjects.</p> </sec> <sec id="jog12499-sec-0003" sec-type="section"> <title>Results</title> <p>The RBP‐4 values in 16–18th weeks of pregnancy were not significantly different between risk and control groups (95.3 ± 20.1 vs 103.1 ± 24.4 μg/mL, respectively; <italic>P</italic> = 0.055) although fasting plasma glucose levels and 50‐g glucose challenge test results were higher in the risk group than the control group (75.3 vs 69.3 mg/dL and 112.4 vs 97.5 mg/dL, respectively; <italic>P</italic> < 0.05).</p> </sec> <sec id="jog12499-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Presence of GDM risk factors does not have an impact on early second trimester RBP‐4 values in pregnant subjects.</p> </sec> </abstract>