The Relationship Between Iron Deficiency in Patients with Helicobacter Pylori‐Infected Nodular Gastritis and the Serum Prohepcidin Level. Issue 1 (25th September 2014)

• Record Type: Journal Article
• Authors: Sato, Yuichi; Yoneyama, Osamu; Azumaya, Masaki; Takeuchi, Manabu; Sasaki, Syun‐ya; Yokoyama, Junji; Shioji, Kazuhiko; Kawauchi, Yusuke; Hashimoto, Satoru; Nishigaki, Yuuki; Kobayashi, Masaaki; Sugimura, Kazuhito; Honma, Terasu; Narisawa, Rintaro; Aoyagi, Yutaka
• Is Part Of: Helicobacter. Volume 20:Issue 1(2015:Feb.)
• Page Start: 11
• Page End: 18
• Publication Date: 2014-09-25
• Subjects: Helicobacter -- Periodicals; Helicobacter infections -- Periodicals; Stomach -- Diseases -- Periodicals; 616.3301405
• DOI: 10.1111/hel.12170
• Languages: English
• ISSNs: 1083-4389

Abstract

<abstract abstract-type="main" id="hel12170-abs-0001"> <title>Abstract</title> <sec id="hel12170-sec-0001" sec-type="section"> <title>Background and aims</title> <p> <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) is recognized as a causative agent for unexplained iron‐deficiency anemia (IDA). We evaluated many background factors influencing an iron‐deficiency state in adult patients with various <italic>H. pylori</italic>‐infected upper gastrointestinal tract diseases.</p> </sec> <sec id="hel12170-sec-0002" sec-type="section"> <title>Method</title> <p>Study 1: <italic>H. pylori‐</italic>infected 121 patients (nodular gastritis (NG) (n = 19), duodenal ulcer (DU) (n = 30), or gastric ulcer (GU) (n = 47), or gastric hyperplastic polyp (GHP) (n = 25)) were enrolled. The RBC count and hemoglobin, iron, ferritin, pepsinogen (PG) I, PG II, gastrin, and anti‐<italic>H. pylori</italic> antibody (Ab) levels in the serum were measured. Study 2: <italic>H. pylori‐</italic>infected 105 patients (NG, n = 19; DU, n = 43; GU, n = 32; GHP, n = 11) and non‐<italic>H. pylori</italic>‐infected individuals (n = 35) were examined for the levels of prohepcidin, ferritin, and iron in the serum. In addition, we measured the data before and after the <italic>H. pylori</italic> eradication.</p> </sec> <sec id="hel12170-sec-0003" sec-type="section"> <title>Results</title> <p>In the patients with GHP and NG, hypoferritinemia was observed in comparison with the GU and DU patients. In the GHP patients, low levels of PG I, a decreased PG I/II ratio, and hypergastrinemia were observed. The levels of serum prohepcidin in the patients with <italic>H. pylori</italic>‐associated disease were higher than those in the uninfected adults. In the patients with NG, the serum prohepcidin levels were higher than those in the other <italic>H. pylori</italic>‐infected patient groups and decreased after the eradication.</p> </sec> <sec id="hel12170-sec-0004" sec-type="section"> <title>Conclusion</title> <p> <italic>H. pylori‐</italic>related iron‐deficiency state might be associated with several factors, such as hypochlorhydria and hepcidin, in patients with GHP or NG.</p> </sec> </abstract>