Correlation Between Helicobacter pylori Infection, IgE Hypersensitivity, and Allergic Disease in Korean Adults. Issue 1 (25th September 2014)

• Record Type: Journal Article
• Authors: Lee, Sang Pyo; Lee, Sun‐Young; Kim, Jeong Hwan; Sung, In‐Kyung; Park, Hyung Seok; Shim, Chan Sup; Moon, Hee‐Won
• Is Part Of: Helicobacter. Volume 20:Issue 1(2015:Feb.)
• Page Start: 49
• Page End: 55
• Publication Date: 2014-09-25
• Subjects: Helicobacter -- Periodicals; Helicobacter infections -- Periodicals; Stomach -- Diseases -- Periodicals; 616.3301405
• DOI: 10.1111/hel.12173
• Languages: English
• ISSNs: 1083-4389

Abstract

<abstract abstract-type="main" id="hel12173-abs-0001"> <title>Abstract</title> <sec id="hel12173-sec-0001" sec-type="section"> <title>Background</title> <p>The correlation between allergic disease and <italic>Helicobacter pylori</italic> infection is still controversial in endemic areas. The aim of this study was to determine whether <italic>H. pylori</italic> infection is related to allergic disease and/or immunoglobulin E (IgE) hypersensitivity in Korean adults.</p> </sec> <sec id="hel12173-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Consecutive Korean adults who visited our center for a routine checkup were enrolled. All subjects completed a questionnaire that was designed to ascertain their medical history pertaining to physician‐diagnosed allergic disease, allergy treatments, and <italic>H. pylori</italic> eradication therapy. Blood was sampled for serum anti‐<italic>H. pylori </italic>IgG antibody. IgE hypersensitivity was measured using a commercially available ImmunoCAP<sup>®</sup> Phadiatop (Phadia AB, Uppsala, Sweden).</p> </sec> <sec id="hel12173-sec-0003" sec-type="section"> <title>Results</title> <p>Of the 3376 Korean adults who were enrolled, 62 did not answer to the questionnaires adequately and were thus excluded. The proportion of noninfected subjects (<italic>p </italic><<italic> </italic>.001) and the prevalence of IgE‐related allergic disease (<italic>p </italic><<italic> </italic>.001) were both highest among those aged <40 years, while the prevalence of non‐IgE‐related allergic disease was highest among those aged ≥70 years (<italic>p </italic><<italic> </italic>.001). Logistic regression analysis revealed that being younger than 40 years was significantly related to the absence of <italic>H. pylori</italic> infection (OR = 2.507, 95% CI = 1.621–3.878, <italic>p </italic><<italic> </italic>.001).</p> </sec> <sec id="hel12173-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The statuses of <italic>H. pylori</italic> infection, IgE hypersensitivity, and allergic diseases differ with age group, there being a higher prevalence of IgE‐related allergic disease and a lower <italic>H. pylori</italic> infection rate among young adults. The hygiene hypothesis might explain these findings in young Koreans, due to the rapid development and improvements in sanitation in Korea.</p> </sec> </abstract>