Enhanced Detection of Protein in Urine by Droplet Evaporation on a Superhydrophobic Plastic. Issue 1 (8th July 2014)

• Record Type: Journal Article
• Authors: McLane, Jolie; Wu, Chun; Khine, Michelle
• Is Part Of: Advanced materials interfaces. Volume 2:Issue 1(2015)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2014-07-08
• Subjects: Materials science -- Periodicals; 620.11
• DOI: 10.1002/admi.201400034
• Languages: English
• ISSNs: 2196-7350

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Protein in urine can be detected using a simple colorimetric output by evaporating droplets on a superhydrophobic (SH) surface. Evaporation on a SH surface allows fluid to dramatically concentrate; the weak surface adhesion allows the droplet of fluid to constantly decrease its footprint area and contact diameter. On a SH surface, pure water completely evaporates. Molecules in solution, however, are confined to a footprint that is 8.5 times smaller than the original and are greatly concentrated. By concentrating molecules, a 160 times improved detection sensitivity is achieved compared to controls. With the low‐cost fabrication method and simple technique, highly sensitive detection can be achieved in a low‐cost platform. Utility is demonstrated by detecting protein in urine in the pre‐eclampsia range (150–300 μgmL⁻¹) for pregnant women.</p> </abstract>